Use sickness

Terraria-style potion sickness: using a matching item gives an effect, and while it lasts every item under rules with the same effect can't be used (an action-bar message says why). Fundamentum assigns no items itself.

File: data/<ns>/fundamentum/sickness/<name>.json

{"items": ["#mymod:healing_potions", "mymod:elixir"], "effect": "fundamentum:potion_sickness", "duration": 1200, "trigger": "finish"}

Field	Default	Meaning
items	required	items and #tags
duration	required	ticks; scaled by the user's fundamentum:sickness_duration attribute
effect	fundamentum:potion_sickness	any mob effect; a mod may use its own (a mana sickness, say)
trigger	finish	finish (after drinking or eating) or use (on right click, for instant items)

Ostentum's apple sickness is one of these: a minute of sickness after an enchanted golden apple.